Extraction, Isolation, Characterization, and Bioactivity of Polypropionates and Related Polyketide Metabolites from the Caribbean Region

The Caribbean region is a hotspot of biodiversity (i.e., algae, sponges, corals, mollusks, microorganisms, cyanobacteria, and dinoflagellates) that produces secondary metabolites such as polyketides polypropionates. Polyketides are diverse class natural products synthesized by organisms through biosynthetic pathway catalyzed polyketide synthase (PKS). This group compounds subdivided into fatty acids, aromatics, polypropionates macrolides, linear cyclic polyethers. Researchers have studied the to find focused on isolation, purification, structural characterization, synthesis, conducting biological assays against parasites, cancer, fungi, bacteria. These studies been summarized in this review, including research from 1981 2020. review includes about 90 isolated meet properties polyketides. Out presented, 73 absolute stereochemical configuration, 82 shown activity. We expect motivate researchers continue exploring region’s marine environments discover investigate new polypropionate products.